195071-49-9 Usage
Description
Amino-PEG4-CH2CO2H is a PEG (polyethylene glycol) linker that features an amino group with a terminal carboxylic acid. This molecule is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous environments. The reactive amino group can form covalent bonds with various functional groups, such as carboxylic acids, activated N-hydroxysuccinimide (NHS) esters, and carbonyls (ketones and aldehydes). Additionally, the terminal carboxylic acid can be used to create stable amide bonds with primary amine groups in the presence of suitable activators, such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N'-dicyclohexylcarbodiimide (DCC).
Uses
Used in Pharmaceutical Industry:
Amino-PEG4-CH2CO2H is used as a molecular linker for enhancing the solubility and bioavailability of drugs. Its hydrophilic PEG spacer improves the water solubility of drug molecules, while the reactive amino and carboxylic acid groups allow for the formation of stable covalent bonds with various drug molecules, potentially improving their pharmacokinetic properties and therapeutic efficacy.
Used in Bioconjugation and Drug Delivery Systems:
In the field of bioconjugation, Amino-PEG4-CH2CO2H serves as a versatile linker for attaching biologically active molecules, such as peptides, proteins, or small molecule drugs, to other biomolecules or surfaces. This can be useful for creating targeted drug delivery systems, where the drug is selectively delivered to specific cells or tissues, reducing side effects and increasing treatment efficacy.
Used in Chemical Synthesis:
Amino-PEG4-CH2CO2H can be employed as an intermediate in the synthesis of various PEGylated compounds, such as PEGylated drugs, polymer therapeutics, and diagnostic agents. The presence of both amino and carboxylic acid functional groups makes it a valuable building block for constructing complex molecular structures with tailored properties and applications.
Used in Surface Modification:
Amino-PEG4-CH2CO2H can be utilized for modifying the surface properties of materials, such as nanoparticles, liposomes, or other drug delivery vehicles. By attaching this PEG linker to the surface, it can improve the stability, circulation time, and biocompatibility of these systems, as well as provide a platform for further functionalization with targeting ligands or therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 195071-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,0,7 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 195071-49:
(8*1)+(7*9)+(6*5)+(5*0)+(4*7)+(3*1)+(2*4)+(1*9)=149
149 % 10 = 9
So 195071-49-9 is a valid CAS Registry Number.
195071-49-9Relevant articles and documents
TARGETED BIFUNCTIONAL DEGRADERS
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, (2021/04/17)
The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.
Protein-inorganic array construction: Design and synthesis of the building blocks
Bogdan, Niculina D.,Matache, Mihaela,Meier, Veronika M.,Dobrotae, Cristian,Dumitru, Ioana,Roiban, Gheorghe D.,Funeriu, Daniel P.
experimental part, p. 2170 - 2180 (2010/07/05)
Herein we describe the design and synthesis of the first series of di-functional ligands for the directed construction of inorganic-protein frameworks. The synthesized ligands are composed of a metal-ion binding moiety (terpyridine-based) conjugated to an epoxysuccinyl peptide, known to covalently bind active cysteine proteases through the active-site cysteine. We explore and optimize two different conjugation chemistries between the di-functionalized metal-ion ligand and the epoxysuccinyl-containing peptide moiety: peptide-bond formation (with limited success) and Cu'-catalysed click chemistry (with good results). Further, the complexation of the synthesized ligands with Fe" and NiII" ions is investigated: the di-functional ligands are confirmed to behave similarly to the parent terpyridine. As designed, the peptidic moiety does not interfere with the complexation reaction, in spite of the presence of two triazole rings that result from the click reaction. ES-MS together with NMR and UV/Vis stud-ies establish the structure, the stoichiometry of the complexation reactions, as well as the conditions under which chemically sensitive peptide-containing polypyridine ligands can undergo the self-assembly process. These results establish the versatility of our approach and open the way to the synthesis of di-functional ligands containing more elaborated polypyridine ligands as well as affinity labels for different enzyme families. As such, this paper is the first step towards the construction of robust supramolecular species that cover a size-regime and organization level previously unexplored.
