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195202-02-9

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195202-02-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 195202-02-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,2,0 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 195202-02:
(8*1)+(7*9)+(6*5)+(5*2)+(4*0)+(3*2)+(2*0)+(1*2)=119
119 % 10 = 9
So 195202-02-9 is a valid CAS Registry Number.

195202-02-9Downstream Products

195202-02-9Relevant articles and documents

A bioorthogonal small-molecule-switch system for controlling protein function in live cells

Liu, Peng,Calderon, Abram,Konstantinidis, Georgios,Hou, Jian,Voss, Stephanie,Chen, Xi,Li, Fu,Banerjee, Soumya,Hoffmann, Jan-Erik,Theiss, Christiane,Dehmelt, Leif,Wu, Yao-Wen

, p. 10049 - 10055 (2015/03/31)

Chemically induced dimerization (CID) has proven to be a powerful tool for modulating protein interactions. However, the traditional dimerizer rapamycin has limitations in certain in vivo applications because of its slow reversibility and its affinity for

Pipecolate-diketoamides for treatment of psychiatric disorders

-

, (2013/07/19)

The present invention relates to compounds having a pipecolate diketoamide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

Gopalakrishnan, Ranganath,Kozany, Christian,Gaali, Steffen,Kress, Christoph,Hoogeland, Bastiaan,Bracher, Andreas,Hausch, Felix

, p. 4114 - 4122 (2012/06/30)

The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders. Rapamycin and FK506 are two macrocyclic natural products that bind to these proteins indiscriminately but with nanomolar affinity. We here report the cocrystal structure of FKBP51 with a simplified α-ketoamide analogue derived from FK506 and the first structure-activity relationship analysis for FKBP51 and FKBP52 based on this compound. In particular, the tert-pentyl group of this ligand was systematically replaced by a cyclohexyl ring system, which more closely resembles the pyranose ring in the high-affinity ligands rapamycin and FK506. The interaction with FKBPs was found to be surprisingly tolerant to the stereochemistry of the attached cyclohexyl substituents. The molecular basis for this tolerance was elucidated by X-ray cocrystallography.

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