195210-09-4 Usage
Description
4-Trifluoromethylumbelliferyl Tetra-O-acetylated α-D-N-Acetylneuraminate Methyl Ester is a complex organic compound that serves as an intermediate in the synthesis of a fluorogenic substrate. This yellow solid is specifically designed to measure the activity of sialidase, an enzyme that plays a crucial role in various biological processes.
Uses
Used in Biochemical Research:
4-Trifluoromethylumbelliferyl Tetra-O-acetylated α-D-N-Acetylneuraminate Methyl Ester is used as a fluorogenic substrate for measuring sialidase activity. The application reason is that it allows researchers to study the function and regulation of sialidase, which is involved in various cellular processes, including cell adhesion, migration, and signal transduction.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Trifluoromethylumbelliferyl Tetra-O-acetylated α-D-N-Acetylneuraminate Methyl Ester is used as a key intermediate in the development of drugs targeting sialidase-related diseases. The application reason is that by understanding and modulating sialidase activity, it may be possible to develop therapeutics for conditions such as influenza, cancer, and neurodegenerative disorders.
Used in Diagnostics:
4-Trifluoromethylumbelliferyl Tetra-O-acetylated α-D-N-Acetylneuraminate Methyl Ester is also used as a diagnostic tool for detecting and monitoring sialidase levels in various samples. The application reason is that it provides a sensitive and specific method for measuring enzyme activity, which can be useful in diagnosing and monitoring the progression of diseases associated with altered sialidase activity.
Check Digit Verification of cas no
The CAS Registry Mumber 195210-09-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,2,1 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 195210-09:
(8*1)+(7*9)+(6*5)+(5*2)+(4*1)+(3*0)+(2*0)+(1*9)=124
124 % 10 = 4
So 195210-09-4 is a valid CAS Registry Number.
195210-09-4Relevant articles and documents
A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors
Buchini, Sabrina,Buschiazzo, Alejandro,Withers, Stephen G.
, p. 2700 - 2703 (2008/12/23)
(Chemical Equation Presented) A substitution for inhibition: The incorporation of anaryl substituent at C9 of 3-fluorosialyl fluorides provides specificity and dramatically slows the reactivation of the glycosylphosphatidylinositol-anchored surface protein Trypanosoma cruzi trans-sialidase (TcTS) by transglycosylation (see picture). X-ray crystallographic analysis of the trapped intermediate has provided a structural rationale for this behavior.
