195307-35-8

Basic information

• Product Name: (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate
• Synonyms: (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate
• CAS NO: 195307-35-8
• Molecular Weight: 1085.23
• Mol File: 195307-35-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate(195307-35-8)
• EPA Substance Registry System: (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate(195307-35-8)

Safety Data

• Hazardous Substances Data: 195307-35-8(Hazardous Substances Data)

Upstream product

• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 114079-04-8 5'-dimethoxytritylthymidine-3'-diisopropylaminomethylphosphonoamidite 
• 676-83-5 methyldichlorophosphane 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 75715-12-7 C₄₂H₄₇N₄O₁₃P 

Relevant articles and documents

Triarylmethyl substituted 4,5-dicyanoimidazoles as activators for Rp- diastereoselective synthesis of TpN dinucleoside methylphosphonates

2-Triarylmethyl-4,5-dicyanoimidazoles 1-3 were synthesized and tested as activators in the methylphosphonamidite approach. TpN dinucleoside methylphosphonates generated showed diastereoselectivity of up to 8/1 (Rp/Sp). The influence of the different triarylmethyl substituents on diastereoselectivity is shown.

Methylphosphonate modified hairpin loops

We synthesized and analyzed DNA hairpin molecules with methylphosphonate linkages of defined stereochemistry in the loop region. Dinucleotide building blocks ApA and TpT (p indicating methylphosphonate linkage with either Rp or Sp configuration) were synt