19533-07-4Relevant articles and documents
Synthesis and characterization of polymerizable one-component photoinitiator based on sesamol
Yang, Jinliang,Tang, Ruifen,Shi, Suqing,Nie, Jun
, p. 923 - 929 (2013)
Migration stability and biocompatibility are the crucial features for a photoinitiator or coinitiator used in UV curable formulations, especially when the cured product is in direct contact with food or human skin. To reduce the migration issues and increase the biocompatibility, a polymerizable one-component photoinitiator, 1-(1,3-benzodioxol-5-yloxy)-3-(4-benzoylphenoxy) propan-2-yl acrylate (BDOBPAc), based on sesamol and benzophenone has been synthesized. The photopolymerization induced by BDOBPAc was monitored by real-time infrared spectroscopy. The rate of decomposition and the migration stability of photoinitiators were studied by UV-Vis spectroscopy. The results showed that BDOBPAc is an effective free radical photoinitiator with good migration stability, which has great potential to be widely used in the food packing or biomedical fields.
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors
Suzuki, Sayaka,Kuroda, Takeshi,Kimoto, Hiroko,Domon, Yuki,Kubota, Kazufumi,Kitano, Yutaka,Yokoyama, Tomihisa,Shimizugawa, Akiko,Sugita, Ryusuke,Koishi, Ryuta,Asano, Daigo,Tamaki, Kazuhiko,Shinozuka, Tsuyoshi,Kobayashi, Hiroyuki
, p. 5419 - 5423 (2015/11/09)
A novel class of NaV1.7 inhibitors has been identified by high-throughput screening followed by structure activity relationship studies. Among this series of compounds, piperidine 9o showed potent human and mouse NaV1.7 inhibitory activities with fair subtype selectivity over NaV1.5. Compound 9o successfully demonstrated analgesic efficacy in mice comparable to that of the currently used drug, mexiletine, but with an expanded central nervous system safety margin.
Photocrosslinked hydrogel blend surface coatings
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, (2008/06/13)
Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.