1954-58-1Relevant articles and documents
Syntheses of 1,2-di-O -palmitoyl-sn -glycero-3-phosphocholine (DPPC) and analogs with 13C- and 2H-labeled choline head groups
Lin, Sonyuan,Duclos Jr., Richard I.,Makriyannis, Alexandros
, p. 171 - 181 (2007/10/03)
The syntheses of four head group labeled analogs of 1,2-di-O-palmitoyl-sn-glycero-3-phosphoc (DPPC) (6) by a general method from 1,2-di-O-palmitoyl-sn -glycero-3-phosphatidic acid (5) have been performed. The syntheses of 1,2-di-O-palmitoyl-sn-glycero-3-phospho[α-13C]choline (6a) and 1,2-di-O-palmitoyl-sn-glycero-3-phospho[β13C]choline (6b) were performed from labeled [l-13C]glycine (1a) in 52% overall yield and from [2-13C]glycine (1b) in 56% overall yield, respectively. 1,2-Di-O-palmitoyl-sn-glycero-3-phosphol[N(C2H3)3]choline (9) was prepared from 2-aminoethanol in 39% overall yield. 1,2-Di- O-palmitoyl-sn-glycero-3-phospho[α-C2H2]choline (12) was prepared from N,N-dimethylglycine ethyl ester in 50% overall yield.