195453-57-7

Basic information

• Product Name: 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
• Synonyms: 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
• CAS NO: 195453-57-7
• Molecular Weight: 377.437
• Mol File: 195453-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester(195453-57-7)
• EPA Substance Registry System: 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester(195453-57-7)

Safety Data

• Hazardous Substances Data: 195453-57-7(Hazardous Substances Data)

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 

Downstream Products

• 195453-67-9 tert-butyl (2S)-1-[(benzyloxy)carbonyl]-2-{[(2S,4R)-4-hydroxy-2-(methoxycarbonyl)pyrrolidin-1-yl]carbonyl}pyrrolidine-2-acetate 
• 195453-64-6 tert-butyl (2R)-1-[(benzyloxy)carbonyl]-2-{[(2S,4R)-4-hydroxy-2-(methoxycarbonyl)pyrrolidin-1-yl]carbonyl}pyrrolidine-2-acetate 
• 195453-86-2 [(2R,5aS,10aS)-5,10-Dioxo-2-(toluene-4-sulfonyloxy)-hexahydro-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl]-acetic acid tert-butyl ester 
• 195453-61-3 2-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 

Relevant articles and documents

111. Synthesis of a novel tricyclic dipeptide template and its incorporation into a cyclic peptide mimetic containing an NPNA motif

A novel tricyclic dipeptide template, formally derived by coupling (2S,4S)-4-aminoproline (Pro(NH2)) and (S)-2-(carhoxymethyl)proline (Pro(CH2COOH)) as a diketopiperazine, has been synthesized in a form suitable for solid-phase peptide synthesis using Fmoc chemistry. This template was incorporated into the cyclic molecule cyclo(-Ala1-Asn2-Pro3- Asn4-Ala5-Ala6-Temp-) (Temp = template), whose conformation in H2O was studied by NMR methods. Average solution structures derived by restrained simulated annealing point to a highly populated βI-turn within the Asn-Pro- Asn-Ala motif and also indicate which conformations are likely to be preferred by the template.