195456-43-0

Basic information

• Product Name: 2-(2-iodophenyl)-acetamide
• Synonyms: 2-(2-iodophenyl)-acetamide
• CAS NO: 195456-43-0
• Molecular Weight: 261.062
• Mol File: 195456-43-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(2-iodophenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-iodophenyl)-acetamide(195456-43-0)
• EPA Substance Registry System: 2-(2-iodophenyl)-acetamide(195456-43-0)

Safety Data

• Hazardous Substances Data: 195456-43-0(Hazardous Substances Data)

Upstream product

• 62300-07-6 o-iodophenylacetyl chloride 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 103-81-1 Benzeneacetamide 
• 18698-96-9 o-iodophenylacetic acid 

Downstream Products

• 39959-51-8 2-iodobenzylamine 
• 1207252-55-8 2-(2-(phenylethynyl)phenyl)acetamide 
• 1069130-86-4 benzyl 3-phenylisoquinoline-2(1H)-carboxylate 
• 1207252-57-0 ethyl 3-phenylisoquinoline-2(1H)-carboxylate 
• 1207252-58-1 methyl 3-phenylisoquinoline-2(1H)-carboxylate 
• 1207252-59-2 ethyl 3-p-tolylisoquinoline-2(1H)-carboxylate 
• 1207252-56-9 2-(2-(p-tolylethynyl)phenyl)acetamide 
• 1566584-26-6 2-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)acetamide 
• 1566584-27-7 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide 
• 4456-77-3 4H-isoquinolin-1,3-dione 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

INHIBITORS

This invention relates to compounds of the formula (I):The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the