1955-67-5 Usage
Description
AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE is a hydroxamic acid derivative of L-glutamine, specifically hydroxylated at the N-5 position. It is a significant compound in the field of biochemistry and has been utilized for various applications due to its unique properties.
Uses
Used in Enzyme Activity Assays:
AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE is used as a standard to calculate transglutaminase (TGase) activity. This application is crucial in the field of biochemistry and molecular biology, as it helps researchers understand the function and regulation of TGase enzymes, which are involved in various cellular processes, including protein cross-linking and signal transduction.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE may be used as a starting material or intermediate in the synthesis of various drugs and therapeutic agents. Its unique structure and properties make it a valuable component in the development of novel pharmaceutical compounds.
Used in Research and Development:
AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE is also used in research and development for studying the structure, function, and interactions of various proteins and enzymes. Its ability to act as a standard for TGase activity assays makes it an essential tool for researchers working on protein function and enzyme mechanisms.
Biochem/physiol Actions
L-Glutamic acid γ-monohydroxamate [L-Glu(gamma)HXM] is used as a vanadium ligand which potentiates vanadiums metabolic activity. L-Glu(gamma)HXM is also used as a substrate for E. coli asparagine synthetase B and as an ATP-dependent irreversible inhibitor of Escherichia coli gamma-glutamylcysteine synthetase.
Check Digit Verification of cas no
The CAS Registry Mumber 1955-67-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,5 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1955-67:
(6*1)+(5*9)+(4*5)+(3*5)+(2*6)+(1*7)=105
105 % 10 = 5
So 1955-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N2O4/c6-4(8)2-1-3(7-11)5(9)10/h3,7,11H,1-2H2,(H2,6,8)(H,9,10)/t3-/m0/s1
1955-67-5Relevant articles and documents
Molecular cloning and characterization of γ-Glutamyltranspeptidase from pseudomonas nitroreducens IFO12694
Imaoka, Masashi,Yano, Shigekazu,Okumura, Masashi,Hibi, Takao,Wakayama, Mamoru
, p. 1936 - 1939 (2011/06/11)
y-Glutamyltranspeptidase from Pseudomonas nitroreducens IFO12694 (PnGGT) exhibited higher hydro-lytic activity than transfer activity, as compared with other y-glutamyltranspeptidases (GGTs). PnGGT showed little activity towards most of L-amino acids and towards glycyl-glycine, which is often used as a standard y-glutamyl accepter in GGT transfer reactions. The preferred substrates for PnGGT as a y-glutamyl accepter were amines such as methylamine, ethylamine, and isopropylamine.
γ-Glutamyl Transfer Reactions by Glutaminase from Pseudomonas nitroreducens IFO 12694 and Their Application for the Syntheses of Theanine and γ-Glutamylmethylamide
Tachiki, Takashi,Yamada, Takeshi,Mizuno, Katsushige,Ueda, Masashi,Shiode, Ju-Ichi,Fukami, Hiroshi
, p. 1279 - 1283 (2007/10/03)
In a mixture containing γ-glutamyl donor (donor) and γ-glutamyl acceptor (acceptor), the glutaminase of Pseudomonas nitroreducens IFO 12694 simultaneously catalyzed a γ-glutamyl transfer reaction and hydrolysis of the donor. The variation of the activities responding to the concentration of glutathione and glycylglycine indicated that the enzyme might be classified in a group of glutaminases that shows hydrolysis prior to transfer reaction. On the other hand, the results with glutamine and ethylamine or methylamine indicated that the enzyme was active in the transfer reaction with suppressed hydrolysis of glutamine, and suggested the possibility of using the reaction for producing γ-glutamylethylamide (theanine) or γ-glutamylmethylamide (γ-GMA). In fact, in a mixture containing high concentrations of substrates (0.7 M glutamine, 1.5 M ethylamine or methylamine) and 0.5 unit/ml glutaminase (borate buffer pH 11), 270 mM (47 g/L) theanine or 250 mM (38 g/L) γ-GMA was formed in 7 h of incubation at 30°C.