195528-46-2Relevant articles and documents
Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles
Chi, Yonggui Robin,Huang, Xiaolei,Nguyen, Minh Hieu,Pu, Maoping,Wu, Yun-Dong,Zhang, Luoqiang,Zhou, Jianrong Steve
, p. 10814 - 10818 (2020)
Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes.
Regioselective ring-opening α-methylenation of aryl epoxides to conjugated allyl alcohols utilizing n-BuLi and Me2S=CH2 reagents
Tomioka, Takashi,Sankranti, Rambabu,James, Amber M.,Mattern, Daniell L.
, p. 3443 - 3445 (2014/06/09)
In the presence of a mixture of n-BuLi and Me2SCH2 reagents, aryl epoxides underwent a novel ring-opening α-methylenation providing conjugated allyl alcohols with an unusual regioselective pattern.