195609-20-2

Basic information

• Product Name: 2-fluoro-5-nitrophenylacetic acid chloride
• Synonyms: 2-fluoro-5-nitrophenylacetic acid chloride
• CAS NO: 195609-20-2
• Molecular Weight: 217.584
• Mol File: 195609-20-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-fluoro-5-nitrophenylacetic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-5-nitrophenylacetic acid chloride(195609-20-2)
• EPA Substance Registry System: 2-fluoro-5-nitrophenylacetic acid chloride(195609-20-2)

Safety Data

• Hazardous Substances Data: 195609-20-2(Hazardous Substances Data)

Upstream product

• 451-82-1 (2-fluorophenyl)acetic acid 
• 195609-18-8 2-(2-fluoro-5-nitrophenyl)acetic acid 

Downstream Products

• 195609-22-4 (2-Fluoro-5-nitrophenyl)acetamide 
• 1255212-95-3 C₃₆H₅₆FN₃O₈Si 
• 1255212-94-2 C₃₆H₅₆FN₃O₈Si 
• 1255212-93-1 C₃₆H₅₆FN₃O₈Si 
• 1255212-92-0 C₃₆H₅₆FN₃O₈Si 
• 1188931-39-6 C₁₄H₁₀FNO₃ 
• 195609-24-6 (2-Fluoro-5-nitro-phenyl)-acetic acid N',N'-dimethyl-hydrazide 
• 195609-28-0 N-(Azepan-1-yl)(2-fluoro-5-nitrophenyl)acetamide 
• 195609-26-8 2-(2-Fluoro-5-nitro-phenyl)-N-piperidin-1-yl-acetamide 

Relevant articles and documents

(±)-1,2-dialkyl-5-nitro-2,3-dihydro-1H-indoles by a tandem reductive amination-SNAr reaction

(Chemical Equation Presented) A tandem reductive amination-SNAr reaction has been applied to the synthesis of (±)-1,2-dialkyl-5-nitro-2, 3-dihydro-1H-indoles. Treatment of a series of 2-fluoro-5-nitrobenzyl ketones with primary amines and sodium cyanoborohydride in methanol at room temperature provided good yields of the target heterocycles. The reaction is sensitive to steric hindrance and proceeds best with less hindered ketone substrates using primary amines that are unbranched at the α carbon.