195609-50-8

Basic information

• Product Name: [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetyl azide
• CAS NO: 195609-50-8
• Molecular Weight: 337.338
• Mol File: 195609-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetyl azide(195609-50-8)
• EPA Substance Registry System: [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetyl azide(195609-50-8)

Safety Data

• Hazardous Substances Data: 195609-50-8(Hazardous Substances Data)

Upstream product

• 195609-40-6 [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetic acid 
• 195609-44-0 [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetic acid methyl ester 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 195609-18-8 2-(2-fluoro-5-nitrophenyl)acetic acid 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 195609-47-3 [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetic acid hydrazide 

Downstream Products

• 195609-40-6 [2-(3,4-Dihydro-1H-isoquinolin-2-yl)-5-nitro-phenyl]-acetic acid 

Relevant articles and documents

Approaches to 1,1-disubstituted cinnolin-3-ylio oxides: Synthesis and reactivity of a new class of heterocyclic betaines

The cinnolin-3-ylio oxides 6, a new class of heterocyclic aminimide, can be prepared by intramolecular cyclization of the N′,N′-disubstituted (2-fluorophenyl)acetohydrazides 5. Attempts to prepare these betaines by an alternative route, namely cyclization of the nitrenes expected from the thermal decomposition of (2-dialkylaminophenyl)acetyl azides 11, failed, Curtius rearrangement-derived compounds being the main products isolated from these processes. Hydrochlorides of the cinnolin-3-ylio oxides 6 undergo alkyl halide elimination to yield the 1-(ω-chloroalkyl)cinnolin-3-ols 19a,b or 1-methylcinnolin-3-ol 21. Oxidation of the latter to the 3-hydroxycinnolin-4-one 22, its methylation to the corresponding N1,O-23 and N1,N2-dimethyl 24 derivatives as well as the cyclization of 1-(5-chloropentyl)cinnolin-3-ol 19a to the diazepino[1,2-a]cinnolinone 20 are also reported.