196085-08-2Relevant articles and documents
Identification of a novel series of potent and selective CCR6 inhibitors as biological probes
Tawaraishi, Taisuke,Sakauchi, Nobuki,Hidaka, Kousuke,Yoshikawa, Kyoko,Okui, Toshitake,Kuno, Haruhiko,Chisaki, Ikumi,Aso, Kazuyoshi
, p. 3067 - 3072 (2018/08/11)
CCR6 has been implicated in both autoimmune diseases and non-autoimmune diseases. Thus, inhibition of CCR6-dependent cell migration is an attractive strategy for their treatment. An orally available small molecule inhibitor of CCR6 could therefore be a us
Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists
Sum, Fuk-Wah,Wong, Victoria,Han, Stella,Largis, Elwood,Mulvey, Ruth,Tillett, Jeff
, p. 2191 - 2194 (2007/10/03)
Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human β3 adrenergic receptor (β3-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent β3-AR agonists and have good selectivity against β1- and β2-AR.