1962-05-6

Basic information

• Product Name: 4,5,6,7-tetrahydro-3-phenylbenzo[d]thiazole-2(3H)-thione
• Synonyms: 4,5,6,7-tetrahydro-3-phenylbenzo[d]thiazole-2(3H)-thione
• CAS NO: 1962-05-6
• Molecular Weight: 247.385
• Mol File: 1962-05-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,5,6,7-tetrahydro-3-phenylbenzo[d]thiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-tetrahydro-3-phenylbenzo[d]thiazole-2(3H)-thione(1962-05-6)
• EPA Substance Registry System: 4,5,6,7-tetrahydro-3-phenylbenzo[d]thiazole-2(3H)-thione(1962-05-6)

Safety Data

• Hazardous Substances Data: 1962-05-6(Hazardous Substances Data)

Upstream product

• 1628-41-7 3a-morpholin-4-yl-3-phenyl-hexahydro-benzothiazole-2-thione 
• 108-94-1 cyclohexanone 
• 1074-52-8 ammonium N-phenyldithiocarbamate 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 40700-17-2 2-methylselanyl-3-phenyl-4,5,6,7-tetrahydro-benzothiazolium; iodide 
• 40700-13-8 3-phenyl-4,5,6,7-tetrahydro-3H-benzothiazole-2-selone 
• 1628-48-4 2-methylsulfanyl-3-phenyl-4,5,6,7-tetrahydro-benzothiazolium; iodide 

Relevant articles and documents

New approaches for the synthesis and ctytotoxicity of thiazoles derived from cyclohexanone

A new class of substituted thiazole derivatives 6a-c which showed promising anticancer activity was synthesized via the reaction of cyclohexanone with phenylisothiocyanate with a good yield. The latter compounds reacted with benzendiazonium chloride to form corresponding 5-phenylazothiazole derivatives 8a and 8b, respectively. Moreover, the reaction of thiazole derivatives 6a-c with each of elemental sulfur and either of malononitrile or ethyl cyanoacetate gave the thiophene derivatives 10a-e, respectively. Compounds 10a-e were subjected to a series of heterocylclization reactions to give heterocyclic derivatives. Their cytotoxicity against four human tumor cells lines was measured and showed promising anticancer activity.