196202-72-9

Basic information

• Product Name: {1-[(E)-5-(4-Carbamimidoyl-phenyl)-3-methoxy-2,2-dimethyl-pent-4-enoyl]-piperidin-4-yl}-acetic acid
• CAS NO: 196202-72-9
• Molecular Weight: 401.506
• Mol File: 196202-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[(E)-5-(4-Carbamimidoyl-phenyl)-3-methoxy-2,2-dimethyl-pent-4-enoyl]-piperidin-4-yl}-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[(E)-5-(4-Carbamimidoyl-phenyl)-3-methoxy-2,2-dimethyl-pent-4-enoyl]-piperidin-4-yl}-acetic acid(196202-72-9)
• EPA Substance Registry System: {1-[(E)-5-(4-Carbamimidoyl-phenyl)-3-methoxy-2,2-dimethyl-pent-4-enoyl]-piperidin-4-yl}-acetic acid(196202-72-9)

Safety Data

• Hazardous Substances Data: 196202-72-9(Hazardous Substances Data)

Upstream product

• 51052-78-9 4-piperidinylacetic acid 
• 196202-65-0 (E)-5-(4-Cyano-phenyl)-3-methoxy-2,2-dimethyl-pent-4-enoic acid tert-butyl ester 
• 196202-64-9 (E)-5-(4-Cyano-phenyl)-2,2-dimethyl-3-oxo-pent-4-enoic acid tert-butyl ester 
• 168986-49-0 4-piperidine acetic acid methyl ester 
• 105-07-7 4-cyanobenzaldehyde 
• 119888-86-7 2,2-Dimethyl-3-oxo-butyric acid tert-butyl ester 
• 28356-58-3 pyridine-4-acetic acid 

Relevant articles and documents

Development of new non-peptide GPIIb-IIIa antagnosts, NSL-95315 and NSL-95317, isosteres of NSL-95300

The synthetic and structure-activity relationship (SAR) studies of new non-peptide GPIIb/IIIa antagonists (1a-f and 3) were conducted by replacing one amide bond of NSL-95300 (2) with an (E)-double bond or an enone group. NSL-95315 (1a) and NSL-95317 (3) showed the inhibitory activity for collagen-induced human platelet aggregation with IC50 values of 0.25 μM and 0.21 μM, respectively.