19645-78-4Relevant articles and documents
C-S and C-N coupling reactions of barbituric acid via selective and complete bromination using greener KBr/H2O2 as a brominating agent
Zade, Mangesh N.,Katiya, Manish M.,Sontakke, Madhuri M.,Dhonde, Madhukar G.,Berad, Baliram N.,Thakare, Vijay J.,Bhaskar, Chandrakant S.
, p. 553 - 558 (2020/07/02)
1,3-Disubstituted/unsubstituted barbituric acids on treatment with KBr-H2O2 as a greener brominating reagent give mono and dibromo barbituric acids. With aqueous HCl selective bromination and without aqueous HCl complete bromination of active methylene group of barbituric acids took place. The reaction of monobarbituric acids with thiosemicarbazide and thioglyoxalic acid under refluxing in aqueous medium, simple C-S coupling products were obtained.The spiro C-N coupling product was obtained by the interaction of dibromo barbituric acid with thiosemicarbazide and C-N condensation product was obtained by the interaction of dibromo barbituric acid with guanidine nitrate, both reactions took place in aqueous medium under refluxing conditions. An environmentally benign, aqueous mediated C-S and C-N organic transformation by the interaction of barbituric acids mediated by KBr-H2O2 as a greener brominating reagent is described. The simple product workup, use of inexpensive greener reagent KBr-H2O2 for bromination and simple purification without column are the additional advantages of synthetic protocol.
Monobromomalononitrile: An efficient regioselective mono brominating agent towards active methylene compounds and enamines under mild conditions
Pathak, Sudipta,Kundu, Ashis,Pramanik, Animesh
, p. 10180 - 10187 (2014/03/21)
The potential of monobromomalononitrile (MBM) as a convenient source of cationic bromine in organic bromination reaction has been explored. Studies reveal that MBM can be a good substitute for N-bromosuccinimide (NBS) in various respects. Enamines and act
Synthesis and evaluation of substituted 5-(3-chloro-2-oxo-4-phenylazetidin- 1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones against pentylenetetrazole-induced convulsant in mice
Puri, Karan Deep Singh,Sood, Shailja,Muthuraman, Arunachalam
, p. 2300 - 2306,7 (2020/07/30)
This study was designed to synthesis of substituted 5-(3-chloro-2-oxo-4- phenylazetidin-1-ylamino)pyrimidine-2,4,6(1H,3H,5H)-triones followed by evaluation against pentylenetetrazole-(PTZ) induced convulsant in mice. The titled compoundswere confirmed by