19682-30-5Relevant articles and documents
A Simple One-Step Synthesis of Steroidal Lactams from Ketones of Spirostane and Cholestan Series
Siddiqui, A. H. U.,Ramesh, D.,Satyanarayana Rao, N.,Sundara Ramaiah, T.
, p. 61 - 62 (2007/10/02)
The steroidal ketones (25R)-7-oxo-5-spirosten-3β-yl methyl ether (1a), (25R)-7-oxo-5-spirosten-3β-yl ethyl ether (1b), 7-oxo-5-cholestene (2a) and 7-oxo-3,5-cholestadiene (3a) afford the respective lactams (4,5,6 and 7) on treatment with hydroxylamine-O-sulphonic acid (HOSA) in hot formic acid.The identity of the lactams obtained by Beckmann rearrangement of the ketoximes (1e, 1f, 2c, 3c) and spectral analysis.