1969-72-8

Basic information

• Product Name: 1-(2-nitrophenyl)propan-2-one
• Synonyms: 1-(2-nitrophenyl)propan-2-one;2-Propanone, 1-(2-nitrophenyl)-;1-(2-Nitrophenyl)Propan-2-One(WX625109)
• CAS NO: 1969-72-8
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17266
• Mol File: 1969-72-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 25-26 °C
• Boiling Point: 111-113 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.212±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(2-nitrophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-nitrophenyl)propan-2-one(1969-72-8)
• EPA Substance Registry System: 1-(2-nitrophenyl)propan-2-one(1969-72-8)

Safety Data

• Hazardous Substances Data: 1969-72-8(Hazardous Substances Data)

Usage

Physical state

Yellowish crystalline solid

Uses

Intermediate in the synthesis of pharmaceuticals and organic compounds

Properties

Exhibits antibacterial and antifungal properties

Potential applications

Development of new antibiotics

Additional uses

Production of fragrances and flavors due to its pleasant, floral aroma

Safety precautions

Toxic and potentially harmful if ingested, inhaled, or absorbed through the skin

Handling

Should be handled with care to avoid exposure and potential health risks

Upstream product

• 186581-53-3 diazomethane 
• 1969-73-9 (2-nitrophenyl)acetaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 61417-33-2 ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate 
• 103-79-7 1-phenyl-acetone 
• 108-22-5 Isopropenyl acetate 
• 119-66-4 2-nitrobenzenediazonium chloride 
• 98-95-3 nitrobenzene 
• 67-64-1 acetone 
• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 108-59-8 malonic acid dimethyl ester 
• 86671-25-2 3-Oxo-4-<2-nitro-phenyl>-butyronitril 
• 60-29-7 diethyl ether 
• 577-19-5 2-nitrophenyl bromide 

Downstream Products

• 77717-34-1 5-methyl-5-(o-nitrobenzyl)hydantoin 
• 95-20-5 2-methyl-1H-indole 
• 85355-52-8 3-(2-nitrophenyl)-2-butanone 
• 64987-76-4 1-(2-nitrophenyl)propan-2-ol 
• 85355-54-0 3-(2-nitrophenyl)-2-pentanone 
• 702643-28-5 3-(2-nitrophenyl)hex-5-en-2-one 
• 702643-35-4 3-(2-nitrophenyl)butan-2-ol 
• 702643-37-6 3-(2-nitrophenyl)pentan-2-ol 
• 702643-39-8 3-(2-nitrophenyl)hex-5-en-2-ol 
• 91-55-4 2,3-dimethylindole 
• 77717-35-2 o-nitro-α-methylphenylalanine hydrobromide 
• 1308803-54-4 3-(2-nitrophenyl)buten-2-one 
• 703-80-0 3-acetylindole 
• 17375-64-3 3-acetyl-2-phenylindole 

Relevant articles and documents

A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis

A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2-hy

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition

Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.