19690-59-6

Basic information

• Product Name: 1-(4-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: 4-CHLORO-2-METHYL-PHENYLHYDRAZINE HYDROCHLORIDE;4-CHLORO-O-TOLYLHYDRAZINE HYDROCHLORIDE;1-(4-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE;BIO-FARMA BF000373;4-chloro-2-tolylhydrazine hydrochloride;1-(4-Chloro-2-methylphenyl)hydrazineHCl;4-CHLORO-O-TOLYLHYDRAZINE HYDROCHLORIDE 96%;4-Chloro-o-tolylhydrazine hydrochloride,96%
• CAS NO: 19690-59-6
• Molecular Formula: C₇H₉ClN₂*ClH
• Molecular Weight: 193.07
• EINECS: 243-227-2
• Mol File: 19690-59-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206-208 °C
• Boiling Point: 300 °C at 760 mmHg
• Flash Point: 135.2 °C
• Appearance: Beige to light purple crystalline powder
• Vapor Pressure: 0.0172mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive: Hygroscopic
• CAS DataBase Reference: 1-(4-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(19690-59-6)
• EPA Substance Registry System: 1-(4-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(19690-59-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 19690-59-6(Hazardous Substances Data)

Usage

Chemical Properties

Beige to light purple crystalline powder

InChI:InChI=1/C7H9ClN2.ClH/c1-5-4-6(8)2-3-7(5)10-9;/h2-4,10H,9H2,1H3;1H

Upstream product

• 95-69-2 4-chloro-2-methylbenzeneamine 

Downstream Products

• 77635-97-3 N-(4-Chloro-2-methyl-phenyl)-N'-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-hydrazine 
• 77635-66-6 N-(4-Chloro-2-methyl-phenyl)-N'-[1-(2-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-86-0 N-(4-Chloro-2-methyl-phenyl)-N'-[1-(4-chloro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-73-5 N-(4-Chloro-2-methyl-phenyl)-N'-[1-(4-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-45-1 N-(4-Chloro-2-methyl-phenyl)-N'-[1-(3-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 110821-30-2 5-amino-1-(4-chloro-2-methyl)phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester 
• 110821-47-1 1-<2-(bromomethyl)-4-chlorophenyl>-1H-pyrazole-4-carboxylic acid, ethyl ester 
• 251443-58-0 1-(4-chloro-2-methylphenyl)-4,5-dihydro-5-(4-methylsulphonylphenyl)-3-trifluoromethyl-1H-pyrazole 
• 921591-16-4 ethyl 5-[4-(benzyloxy)phenyl]-1-(4-chloro-2-methylphenyl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1048669-99-3 ethyl 5-tert-butyl-1-(4-chloro-2-methylphenyl)-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains

The spread of infections caused by multidrug-resistant (MDR) pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), has created a need for new antibiotics with novel mechanisms of action. The bacterial division protein FtsZ has been identified as a novel drug target that can be exploited clinically. As part of an ongoing effort to develop FtsZ-targeting antibacterial agents, we describe herein the design, synthesis and bioactivity of six series of novel 1,3,4-oxadiazol-2-one-containing, 1,2,4-triazol-3-one-containing and pyrazolin-5-one-containing benzamide derivatives. Among them, compound A14 was found to be the most potent antibacterial agent, much better than clinical drugs such as ciprofloxacin, linezolid and erythromycin against all the tested gram-positive strains, particularly methicillin-resistant, penicillin-resistant and clinical isolated S. aureus. Subsequent studies on biological activities and docking analyses proved that A14 functioned as an effective compound targeting FtsZ. Preliminary SAR indicated a general direction for further optimization of these novel analogues. Taken together, this research provides a promising chemotype for developing newer FtsZ-targeting bactericidal agents.