197070-47-6

Basic information

• Product Name: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• Synonyms: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• CAS NO: 197070-47-6
• Molecular Weight: 432.592
• Mol File: 197070-47-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione(197070-47-6)
• EPA Substance Registry System: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione(197070-47-6)

Safety Data

• Hazardous Substances Data: 197070-47-6(Hazardous Substances Data)

Upstream product

• 131118-61-1 3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 183892-50-4 4'-C-benzoylthymidine 
• 183892-68-4 4'-C-benzoyl-5'-O-(4,4'-dimethoxytrityl)thymidine 
• 183892-57-1 1-((2R,4S,5S)-5-Benzoyl-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 183892-55-9 1-[(2R,4S,5S)-5-Benzoyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

165. Synthesis of 4′-C-acylated thymidines

Two synthetic pathways towards 4′-C-acylthymidines are presented. These modified mononucleosides are precursors of the 2′-deoxyribonucleotide 4′-C-radical. They were converted into their corresponding 3′-O-[(2-cyanoethyl) N,N-diisopropylphosphoramidites]