197223-37-3

Basic information

• Product Name: tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate
• Synonyms: tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate
• CAS NO: 197223-37-3
• Molecular Weight: 564.72
• Mol File: 197223-37-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate(197223-37-3)
• EPA Substance Registry System: tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate(197223-37-3)

Safety Data

• Hazardous Substances Data: 197223-37-3(Hazardous Substances Data)

Upstream product

• 124620-51-5 (S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-5-hydroxypentanoate 
• 5891-45-2 (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester 
• 16874-06-9 di-tert-butyl L-glutamate 
• 159877-09-5 tert-butyl (2S)-5-methylsulphonyloxy-2-(benzyloxycarbonylamino)pentanoate 

Downstream Products

• 197223-42-0 tert-butyl (2S)-2-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate 

Relevant articles and documents

Synthesis of novel quinazoline-based antifolates with modified glutamate side chains as potential inhibitors of thymidylate synthase and antitumour agents

Several novel antifolates, derivatives of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid, were synthesised as inhibitors of thymidylate synthase (TS) and antitumour agents. This was accomplished by first developing routes to the key in