197227-85-3 Usage
Description
Adenosine-15N N1-Oxide is a chemical compound derived from adenosine, a nucleoside composed of adenine attached to a ribose sugar molecule. The compound is characterized by the presence of an additional nitrogen isotope (15N) and an oxide group at the N1 position. It is a yellow solid and has been found to have potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
Adenosine-15N N1-Oxide is used as an active ingredient for the preparation of therapeutic agents targeting inflammatory diseases. Its application is based on its ability to modulate cellular processes and pathways involved in inflammation, providing a potential treatment option for conditions characterized by excessive or chronic inflammation.
Additionally, Adenosine-15N N1-Oxide is used as an inhibitor of adenosine kinase, an enzyme that plays a crucial role in the regulation of adenosine levels within cells. By inhibiting this enzyme, the compound can potentially influence cellular processes and signaling pathways, making it a valuable tool in the development of new therapeutic strategies for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 197227-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,2,2 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 197227-85:
(8*1)+(7*9)+(6*7)+(5*2)+(4*2)+(3*7)+(2*8)+(1*5)=173
173 % 10 = 3
So 197227-85-3 is a valid CAS Registry Number.
197227-85-3Relevant articles and documents
Use of a 13C atom to differentiate two 15N-labeled nucleosides
Zhao,Pagano,Wang,Shallop,Gaffney,Jones
, p. 7832 - 7835 (2007/10/03)
We report the first examples of the specifically 15N and 13C multilabeled nucleosides: [1,NH2-15N2]- and [2-13C-1,NH2-15N2-]- guanosine; [1,7,NH2-15N3]- and [2-13C-1,7,NH2-15N3]-2'- deoxyguanosine. In each set, the [13C] atom functions as a 'tag' that allows the N1 and N2 15N atoms of two 15N-labeled guanines to be unambiguously differentiated in RNA and DNA fragments. The syntheses employ high-yield reactions in which protecting groups are not required and use relatively low cost sources of isotopes: [15N]-ammonium chloride and [15N]- or [13C,15N]-potassium cyanide.
