197719-57-6

Basic information

• Product Name: 4-Methyl-benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS NO: 197719-57-6
• Molecular Weight: 474.629
• Mol File: 197719-57-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Methyl-benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(197719-57-6)
• EPA Substance Registry System: 4-Methyl-benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester(197719-57-6)

Safety Data

• Hazardous Substances Data: 197719-57-6(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 50-89-5 thymidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 35898-26-1 O^5'-(4-methyl-benzoyl)-thymidine 

Relevant articles and documents

Facile preparation of protected furanoid glycals from thymidine

The synthesis of O-silyl- and O-acyl-protected furanose glycals from free thymidine was investigated. The method of glycal formation reported by Pedersen et al. was successfully expanded to include 5-ester (toluoyl) protected glycals as well as various combinations of 5'-ester and 3- and 5- tert-butyldimethylsilyl and tert-butyldiphenylsilyl protection. Gram quantities of furanoid glycals can be prepared in a few days in two-four steps in overall yields ranging from 17 to 80%.