1978-88-7

Basic information

• Product Name: N-(4-chlorophenyl)-4-fluorobenzamide
• Synonyms: N-(4-chlorophenyl)-4-fluorobenzamide
• CAS NO: 1978-88-7
• Molecular Formula: C₁₃H₉ClFNO
• Molecular Weight: 249.6680632
• Mol File: 1978-88-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 171-172 °C(Solv: methanol (67-56-1); water (7732-18-5))
• Boiling Point: 287.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• PKA: 12.52±0.70(Predicted)
• CAS DataBase Reference: N-(4-chlorophenyl)-4-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-fluorobenzamide(1978-88-7)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-fluorobenzamide(1978-88-7)

Safety Data

• Hazardous Substances Data: 1978-88-7(Hazardous Substances Data)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 106-47-8 4-chloro-aniline 
• 462-06-6 fluorobenzene 
• 104-12-1 p-chlorphenylisocyanate 
• 106-39-8 bromochlorobenzene 
• 824-75-9 p-fluorobenzamide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 140-75-0 para-fluorobenzylamine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 72755-09-0 4-fluoro-N-methoxybenzamide 

Relevant articles and documents

Studies towards the design and synthesis of novel 1,5-diaryl-1h-imidazole-4-carboxylic acids and 1,5-diaryl-1h-imidazole-4-carbohydrazides as host ledgf/p75 and hiv-1 integrase interaction inhibitors

Two targeted sets of novel 1,5-diaryl-1H-imidazole-4-carboxylic acids 10 and carbohy-drazides 11 were designed and synthesized from their corresponding ester intermediates 17, which were prepared via cycloaddition of ethyl isocyanoacetate 16 and diarylimi

Green synthetic method of N-arylamides using recyclable cheap metal catalyst

Magnetically separable and reusable Fe/Cu oxide (Fe3O4-Cu2O) nanoparticles were employed as an efficient catalyst for the arylation of benzamide, which was carried out with a range of both arylboronic acid and benzamide to afford N-arylamide in good to excellent yield.

Synthesis of 2-aminobenzophenone derivatives and their anticancer activity

A number of 2-aminobenzophenones have been synthesized by acylation of para-chloroaniline with different 2-, 3-, 4-chloro-or fluorobenzoyl chloride in solid state via the Friedel-Crafts reaction. Synthesized compounds were characterized by 1H and 13C NMR, Fourier transform-infrared, ultraviolet-visible spectroscopy, mass spectrometry, and elemental analysis. Evaluation of biological activity in vitro showed that the selected compounds 9, 10, and 13 have potential anticancer activity. The presence of one chlorine atom in the second aromatic ring of the benzophenone molecule makes it more active.