197890-44-1

Basic information

• Product Name: GW311616A
• Synonyms: GW-1616A; GW-311616A
• CAS NO: 197890-44-1
• Molecular Formula: C19H32ClN3O4S
• Molecular Weight: 433.99308
• Mol File: 197890-44-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /solid
• Storage Temp.: 2-8°C
• Solubility: H2O: 24 mg/mL, soluble
• CAS DataBase Reference: GW311616A(CAS DataBase Reference)
• NIST Chemistry Reference: GW311616A(197890-44-1)
• EPA Substance Registry System: GW311616A(197890-44-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 197890-44-1(Hazardous Substances Data)

Usage

Description

GW311616 hydrochloride, also known as GW 311616A, is a potent and selective inhibitor of neutrophil elastase, a serine protease enzyme predominantly found in neutrophils. It exhibits high specificity for neutrophil elastase over other serine proteases such as trypsin, cathepsin G, plasmin, chymotrypsin, and tissue plasminogen activator. GW311616 hydrochloride has demonstrated the ability to inhibit the formation of neutrophil extracellular traps (NETs) and intraneutrophil elastase activity, making it a promising candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
GW311616 hydrochloride is used as a therapeutic agent for the treatment of conditions associated with excessive neutrophil elastase activity. Its application is particularly relevant in the management of inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and acute respiratory distress syndrome (ARDS), where neutrophil elastase-mediated tissue damage plays a significant role.
Used in Research Applications:
In the field of research, GW311616 hydrochloride serves as a valuable tool for studying the role of neutrophil elastase in various biological processes and disease mechanisms. It can be employed to investigate the effects of neutrophil elastase inhibition on cellular functions, such as the formation of NETs, and to explore the potential of targeting this enzyme for therapeutic intervention in different pathological conditions.
Used in Drug Development:
GW311616 hydrochloride can be utilized in the development of novel drugs targeting neutrophil elastase for the treatment of diseases where this enzyme plays a critical role. Its high selectivity and potency make it an attractive starting point for the design and optimization of new inhibitors with improved pharmacokinetic and pharmacodynamic properties.
Used in Preclinical Models:
GW311616 hydrochloride is used as a pharmacological agent in preclinical models to evaluate the efficacy and safety of neutrophil elastase inhibition in animal models of disease. It can help researchers understand the potential benefits and risks associated with targeting neutrophil elastase in specific disease contexts, such as liver ischemia-reperfusion injury, and guide the development of more effective therapeutic strategies.

references

[1] macdonald sj1, dowle md, harrison la, shah p, johnson mr, inglis gg, clarke gd, smith ra, humphreys d, molloy cr, amour a, dixon m, murkitt g, godward re, padfield t, skarzynski t, singh om, kumar ka, fleetwood g, hodgson st, hardy gw, finch h. the discovery of a potent, intracellular, orally bioavailable,long duration inhibitor of human neutrophil elastase-gw311616a a development candidate. bioorg med chem lett. 2001 apr 9;11(7):895-8.