19790-62-6

Basic information

• Product Name: Butanal, 4-phenoxy-
• CAS NO: 19790-62-6
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol File: 19790-62-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Butanal, 4-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanal, 4-phenoxy-(19790-62-6)
• EPA Substance Registry System: Butanal, 4-phenoxy-(19790-62-6)

Safety Data

• Hazardous Substances Data: 19790-62-6(Hazardous Substances Data)

Usage

Description

Butanal, 4-phenoxy-, also known as 4-Phenoxybutanal, is a chemical compound characterized by the molecular formula C10H12O2. It is a pale yellow liquid that emits a floral scent, making it a popular choice as a fragrance ingredient in a variety of consumer products. Additionally, it serves as an intermediate in the synthesis of other chemicals. While it has demonstrated low acute oral toxicity in animal studies, there is limited information on its potential health effects in humans, necessitating careful handling and adherence to safety protocols during its use.

Uses

Used in Fragrance Industry:
Butanal, 4-phenoxy-, is utilized as a fragrance ingredient due to its floral odor, enhancing the scent profiles of various consumer products such as perfumes, cosmetics, and personal care items.
Used in Chemical Synthesis:
In the chemical industry, Butanal, 4-phenoxy-, serves as an intermediate for the synthesis of other chemicals, contributing to the creation of a range of products that require its specific chemical properties.

Upstream product

• 201230-82-2 carbon monoxide 
• 1746-13-0 allyl phenyl ether 
• 108-95-2 phenol 
• 2653-89-6 4-phenoxy-1-butene 
• 32833-70-8 4-phenoxybut-2-yn-1-ol 
• 589-10-6 phenoxyethyl bromide 
• 87841-81-4 1-phenoxy-2-<(1-methylethylidene)hydrazino>ethane 
• 3184-38-1 1-phenoxy-2-hydrazinoethane 
• 32117-82-1 N-methoxy-N-methyl-formamide 
• 63985-67-1 (3-phenoxypropyl)triphenylphosphonium bromide 
• 87841-77-8 2-(2-Phenoxy-ethylazo)-prop-2-yl-hydroperoxide 
• 109-92-2 ethyl vinyl ether 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 

Downstream Products

• 358349-92-5 (4-phenoxybutyl)benzene 
• 2653-86-3 (pent-4-en-1-yloxy)benzene 
• 19790-68-2 4-phenoxy-butyraldehyde-semicarbazone 

Relevant articles and documents

Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes

Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.

Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation

Air-stable and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were employed in rhodium-catalyzed asymmetric hydroformylation of various terminal olefins with excellent conversions (>99%), moderate-to-excellent enantioselectivities (up to 95:5 er), and branched to linear ratios (b:l) of up to 400.

Easily accessible and highly tunable bisphosphine ligands for asymmetric hydroformylation of terminal and internal alkenes

An efficient methodology for synthesizing a small library of easily tunable and sterically bulky ligands for asymmetric hydroformylation (AHF) has been reported. Five groups of alkene substrates have been tested with excellent conversions, moderate-to-excellent regio- and enantioselectivities. Among the best result of the reported literature, application of ligand 1 c in the highly selective AHF of the challenging substrate 2,5-dihydrofuran yielded almost one isomer in up to 99 % conversion along with enantiomeric excesses (ee) of up to 92 %. Highly enantioselective AHF of dihydropyrrole substrates is achieved using the same ligand, with up to 95 % ee and up to >1:50 β-isomer/α- isomer ratio. The simpler the better! An efficient method for the easy and tunable synthesis of a series of asymmetric hydroformylation (AHF) ligands from low-cost, commercially available starting materials has been reported. These ligands can give excellent conversions and moderate to excellent regio- and enantioselectivities for a broad range of mono- and disubstituted alkenes with a low catalyst loading (substrate-to-catalyst ratios (S/C) of 1000:1 to 3000:1).