1979149-35-3

Basic information

• Product Name: ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrole-2-carboxylate
• CAS NO: 1979149-35-3
• Molecular Weight: 221.256
• Mol File: 1979149-35-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrole-2-carboxylate(1979149-35-3)
• EPA Substance Registry System: ethyl 8-oxo-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrole-2-carboxylate(1979149-35-3)

Safety Data

• Hazardous Substances Data: 1979149-35-3(Hazardous Substances Data)

Upstream product

• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 53715-97-2 5,5'-oxybis(5-oxopentanoic acid) 

Relevant articles and documents

Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers

A new series of pyrrolo[3′,2′:6,7]cyclohepta[1,2-d]pyrimidin-2-amines, was conveniently prepared using a versatile and high yielding multistep sequence. A good number of derivatives was obtained and the cellular photocytotoxicity was evaluated in?vitro against three different human tumor cell lines with EC50(0.08–4.96?μM) values reaching the nanomolar level. Selected compounds were investigated by laser flash photolysis. The most photocytotoxic derivative, exhibiting a fairly long-lived triplet state (τ ～ 7?μs) and absorbance in the UV–Vis, was tested in the photo-oxidations of 9,10-anthracenedipropionic acid (ADPA) by singlet oxygen. The photosentizing properties are responsible for the compounds’ ability to photoinduce massive cell death with involvement of mitochondria.