19793-95-4Relevant articles and documents
Synthesis of 2-(1,2,3-Triazolyl)benzamide Derivatives by a Copper(I)-Catalyzed Multicomponent Reaction
Hayeebueraheng, Abdulhakim,Kaewmee, Benyapa,Rukachaisirikul, Vatcharin,Kaeobamrung, Juthanat
, p. 6714 - 6721 (2017/12/07)
The copper-catalyzed multicomponent reaction of 2-iodobenzamides, NaN3, and terminal alkynes for the synthesis of 2-(1,2,3-triazolyl)benzamide derivatives was achieved in a one-step process over a short period of time under mild conditions. The transformation involved a C(aryl)–N bond formation process followed by an azide–alkyne cycloadditon reaction. The absence of external base was crucial for the preferred reaction pathway to occur.
Selective cyclization of alkynols and alkynylamines catalyzed by potassium tert-butoxide
Li, Deng Yuan,Shi, Ke Ji,Mao, Xiao Feng,Le Zhao, Zheng,Wu, Xin Yan,Liu, Pei Nian
, p. 7022 - 7031 (2015/03/14)
Potassium tert-butoxide (t-BuOK) was found to be an effective catalyst for the cyclization of aromatic alkynols and alkynylamines. In the presence of 10 mol % t-BuOK, a range of alkynols were converted to the corresponding exo-cyclic enol ethers as pure Z
Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones
Zhou, Yu,Zhai, Yun,Li, Jian,Ye, Deju,Jiang, Hualiang,Liu, Hong
supporting information; experimental part, p. 1397 - 1404 (2010/09/16)
A mild and effective method was developed for the construction of heterocyclic building blocks 3-hydroxyisoindolin-1-ones via a metal-free tandem transformation with excellent regioselectivity. Significantly, the strategy presents an atom-economical and environmentally friendly transformation, in which two new C-N bonds and one C-O bond are formed in water from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.
