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197959-76-5

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197959-76-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 197959-76-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,9,5 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 197959-76:
(8*1)+(7*9)+(6*7)+(5*9)+(4*5)+(3*9)+(2*7)+(1*6)=225
225 % 10 = 5
So 197959-76-5 is a valid CAS Registry Number.

197959-76-5Relevant articles and documents

AMIDINOHYDRAZONES AS PROTEASE INHIBITORS

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Page/Page column 26, (2010/11/23)

Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.

Amidinohydrazones as guanidine bioisosteres: Application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors

Soll, Richard M.,Lu, Tianobao,Tomczuk, Bruce,Illig, Carl R.,Fedde, Cynthia,Eisennagel, Stephen,Bone, Roger,Murphy, Larry,Spurlino, John,Salemme, F. Raymond

, p. 1 - 4 (2007/10/03)

We describe a new class of potent, non-amide-based small molecule thrombin inhibitors in which an amidinohydrazone is used as a guanidine bioisostere on a non-peptide scaffold. Compound 4 exhibits nM inhibition of thrombin, is selective for thrombin, and

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