19805-18-6

Basic information

• Product Name: 1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
• Synonyms: 1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE;18:1 TRANS PE;18:1 (Δ9-Trans) PE
• CAS NO: 19805-18-6
• Molecular Formula: C₄₁H₇₈NO₈P
• Molecular Weight: 744.03
• Mol File: 19805-18-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 759.2±70.0 °C(Predicted)
• Appearance: /
• Density: 1.008±0.06 g/cm3(Predicted)
• PKA: 1.17±0.50(Predicted)
• CAS DataBase Reference: 1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE(19805-18-6)
• EPA Substance Registry System: 1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE(19805-18-6)

Safety Data

• Hazardous Substances Data: 19805-18-6(Hazardous Substances Data)

Usage

Description

1,2-DIELAIDOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, commonly referred to as DEPE, is a complex lipid molecule that plays a significant role in cellular membrane structure and function. It is characterized by the presence of two fatty acid chains attached to the sn-glycerol-3-phosphate backbone, with an ethanolamine phosphate group at the third position. This unique structure endows DEPE with various biological properties and potential applications in the pharmaceutical industry.

Uses

Used in Pharmaceutical Composition:
DEPE is used as a KRAS variant mRNA molecule for pharmaceutical composition, which is particularly useful for treating cancer. The KRAS protein, when mutated, is known to drive the development and progression of various types of cancer. By targeting these specific mRNA molecules, DEPE has the potential to modulate the expression of KRAS variants, thereby inhibiting tumor growth and improving patient outcomes.
Used in Cancer Research and Drug Development:
In the field of cancer research, DEPE can be employed as a key component in the development of novel therapeutic strategies. Its unique structure allows for the design of targeted drug delivery systems, which can specifically address the altered lipid composition of cancer cells. This targeted approach can enhance the efficacy of chemotherapy and reduce side effects associated with conventional treatments.
Used in Drug Delivery Systems:
Similar to gallotannin, DEPE can also be incorporated into various drug delivery systems to improve its bioavailability and therapeutic outcomes. Organic and metallic nanoparticles can be used as carriers for DEPE, enabling its efficient delivery to cancer cells and enhancing its anticancer properties.
Used in Anticancer Applications:
DEPE can be utilized as an anticancer agent, targeting the lipid metabolism of cancer cells and disrupting the cellular processes that support tumor growth. Its ability to modulate the expression of KRAS variant mRNA molecules makes it a promising candidate for the development of new cancer therapies, particularly for patients with KRAS-mutated tumors.

Upstream product

• 71260-21-4 (Z)-Octadec-9-enoic acid 1-((Z)-octadec-9-enoyloxymethyl)-2-{(2,2,2-tribromo-ethoxy)-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 
• 71260-68-9 (Z)-Octadec-9-enoic acid 1-((Z)-octadec-9-enoyloxymethyl)-2-[phenylamino-(2,2,2-tribromo-ethoxy)-phosphoryloxy]-ethyl ester 
• 71260-73-6 (Z)-Octadec-9-enoic acid 2-[hydroxy-(2,2,2-tribromo-ethoxy)-phosphoryloxy]-1-((Z)-octadec-9-enoyloxymethyl)-ethyl ester 
• 2442-61-7 1,2-dioleoylglycerol 
• 69747-56-4 (Z)-Octadec-9-enoic acid 2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-1-((Z)-octadec-9-enoyloxymethyl)-ethyl ester 

Downstream Products

• 1438280-68-2 (Z)-3-((hydroxy(2-(2-((4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamido)ethoxy)phosphoryl)oxy)propane-1,2-diyl dioleate