198062-93-0

Basic information

• Product Name: S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate
• Synonyms: S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate
• CAS NO: 198062-93-0
• Molecular Weight: 273.356
• Mol File: 198062-93-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate(198062-93-0)
• EPA Substance Registry System: S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate(198062-93-0)

Safety Data

• Hazardous Substances Data: 198062-93-0(Hazardous Substances Data)

Upstream product

• 198062-96-3 O-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate 
• 831-82-3 4-Phenoxyphenol 
• 38778-05-1 4-(Phenoxy)benzenethiol 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 

Downstream Products

• 38778-05-1 4-(Phenoxy)benzenethiol 
• 292605-13-1 3-(4-phenoxyphenylsulfonyl)propyloxirane 
• 292605-12-0 2-(4-phenoxyphenylsulfonyl)ethyloxirane 
• 292605-14-2 SB-3CT 
• 292605-11-9 2-{[(4-phenoxyphenyl)sulfonyl]methyl}oxirane 
• 292605-10-8 5-(4-phenoxyphenylsulfanyl)-1-pentene 
• 292605-09-5 4-(4-phenoxyphenylsulfanyl)-1-butene 
• 3159-49-7 3-(4-phenoxyphenylsulfanyl)-1-propene 

Relevant articles and documents

Potent and selective mechanism-based inhibition of gelafinases [18]

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Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents

α-Methylacyl-CoA racemase (AMACR; P504S) catalyses an essential step in the degradation of branched-chain fatty acids and the activation of ibuprofen and related drugs. AMACR has gained much attention as a drug target and biomarker, since it is found at elevated levels in prostate cancer and several other cancers. Herein, we report the synthesis of 2-(phenylthio)propanoyl-CoA derivatives which provided potent AMACR inhibitory activity (IC50 = 22–100 nM), as measured by the AMACR colorimetric activity assay. Inhibitor potency positively correlates with calculated logP, although 2-(3-benzyloxyphenylthio)propanoyl-CoA and 2-(4-(2-methylpropoxy)phenylthio)propanoyl-CoA were more potent than predicted by this parameter. Subsequently, carboxylic acid precursors were evaluated against androgen-dependent LnCaP prostate cancer cells and androgen-independent Du145 and PC3 prostate cancer cells using the MTS assay. All tested precursor acids showed inhibitory activity against LnCaP, Du145 and PC3 cells at 500 μM, but lacked activity at 100 μM. This is the first extensive structure-activity relationship study on the influence of side-chain interactions on the potency of novel rationally designed AMACR inhibitors.

INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS

The invention provides methods to treat neurological disorders, ophthalmological disorders, or a combination thereof by administering a compound that inhibits MMPs. A compound that inhibits MMPs is represented by the compound of formula (I) shown herein.