198127-99-0Relevant articles and documents
Polyfunctionalisation of imidazole via sequential imidazolyl anion formation
Carver, David S.,Lindell, Stephen D.,Saville-Stones, Elizabeth A.
, p. 14481 - 14496 (1997)
A method for achieving the sequential functionalisation of the imidazole ring in the order C-5→C-4→C-2 is described. The chemistry proceeds via the regioselective formation of positionally stable imidazolyl anions which are reacted with electrophiles (aldehydes, alkyl halides, azides, formamides, isocyanates) to afford substituted imidazoles in 31-90% yield.