198135-19-2

Basic information

• Product Name: 5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester
• Synonyms: 5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester
• CAS NO: 198135-19-2
• Molecular Weight: 288.303
• Mol File: 198135-19-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester(198135-19-2)
• EPA Substance Registry System: 5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester(198135-19-2)

Safety Data

• Hazardous Substances Data: 198135-19-2(Hazardous Substances Data)

Upstream product

• 60083-22-9 ethyl (2E)-3-oxo-2-(2-phenylhydrazinylidene)butanoate 
• 146000-76-2 C₆H₉N₃O₃ 
• 105-45-3 acetoacetic acid methyl ester 
• 100-63-0 phenylhydrazine 
• 64-17-5 ethanol 
• 198135-47-6 4-(methoxycarbonyl)-5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 268544-98-5 methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate 
• 268544-93-0 methyl 3-tert-butylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate 
• 1026593-28-1 3-chlorocarbonyl-5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 198135-47-6 4-(methoxycarbonyl)-5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 77936-92-6 5-methyl-1-phenyl-1H-pyrazole-3,4-dicarboxylic acid 

Relevant articles and documents

Expeditious solid-phase synthesis of pyrazoledicarboxylic acid derivatives by functionalization of resin-bound cyanoformate

Esterification of the Wang resin 5 with the monoamide of oxalic acid (oxamic acid, 7) followed by dehydration of the amide function furnishes the resin-bound cyanoformate 9, which can be elaborated by zinc-catalyzed reaction with β-keto esters. The obtained enamino keto diesters 10a-d react with hydrazines affording, after removal from the solid support, fully substituted pyrazoledicarboxylic acids 12a-n. Optimization of the above sequence and the solid-phase synthesis of a small test-library of 1,5-disubstituted pyrazole-3,4-dicarboxylic acid derivatives are described. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.