198544-42-2 Usage
Description
FMOC-D-DAP(BOC)-OH, also known as N-(9-fluorenylmethoxycarbonyl)-D-2,3-diaminopropionic acid tert-butyl ester, is a synthetic amino acid derivative that serves as a crucial building block in the field of peptide synthesis. It is characterized by its white to off-white crystalline powder appearance and plays a significant role in the development of peptide-based drugs due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
FMOC-D-DAP(BOC)-OH is used as an amino acid building block for peptide synthesis, which is essential in the development of peptide-based drugs. The growing peptide drug market necessitates the fast and reliable synthesis of peptides, making FMOC-D-DAP(BOC)-OH a valuable component in this industry.
Used in Research and Development:
In the field of research and development, FMOC-D-DAP(BOC)-OH is utilized as a key component in the synthesis of various peptides for studying their biological activities and potential therapeutic applications. Its unique chemical properties allow for the creation of novel peptide sequences with specific functions and properties.
Used in Drug Discovery:
FMOC-D-DAP(BOC)-OH plays a vital role in drug discovery, as it can be used to create a wide range of peptide-based therapeutics. These peptides can target specific biological pathways or receptors, potentially leading to the development of new treatments for various diseases and conditions.
Used in Custom Peptide Synthesis:
FMOC-D-DAP(BOC)-OH is also used in custom peptide synthesis, where researchers and scientists can design and create peptides with specific sequences and functionalities. This allows for the development of tailored therapeutics that can target specific diseases or conditions more effectively.
Check Digit Verification of cas no
The CAS Registry Mumber 198544-42-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,5,4 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 198544-42:
(8*1)+(7*9)+(6*8)+(5*5)+(4*4)+(3*4)+(2*4)+(1*2)=182
182 % 10 = 2
So 198544-42-2 is a valid CAS Registry Number.
198544-42-2Relevant articles and documents
Synthesis of alanine and proline amino acids with amino or guanidinium substitution on the side chain
Zhang, Zhenyu,Aerschot, Arthur Van,Hendrix, Chris,Busson, Roger,David, Frank,Sandra, Pat,Herdewijn, Piet
, p. 2513 - 2522 (2000)
Competitive binding of peptides containing basic amino acids to disrupt or prevent the Tat-TAR interaction could result in diminished transcription as well as translation and hence constitutes an alternative way of controlling HIV replication. Therefore, we synthesized guanidinium and amino containing amino acids, based on a proline or an alanine scaffold. The introduction of the guanidinium moiety was best accomplished using 1H- pyrazole-1-carboxamidine hydrochloride, with Pmc used for its protection. The absence of racemization, maintained throughout the whole synthesis, was confirmed by chiral purity determination. These building blocks were smoothly incorporated into oligopeptides, which proved their suitability for use in a combinatorial approach for selecting TAR binding ligands. (C) 2000 Elsevier Science Ltd.
