198549-12-1Relevant articles and documents
IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS
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Page/Page column 100, (2014/09/03)
The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various or
Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions; intramolecular reactions with 1,2,4-triazines
Neipp, Christopher E.,Ranslow, Peter B.,Wan, Zhaokui,Snyder, John K.
, p. 7499 - 7502 (2007/10/03)
Imidazole and 2-phenylimidazole undergo intramolecular cycloadditions with 1,2,4-triazines tethered between an imidazole nitrogen and the triazinyl C3 position with a trimethylene chain to produce tetrahydro-1,5-naphthyridines following loss of N2/s