19859-90-6

Basic information

• Product Name: Benzoic acid, 4-methoxy-3,5-bis(phenylmethoxy)-
• CAS NO: 19859-90-6
• Molecular Formula: C22H20O5
• Molecular Weight: 364.398
• Mol File: 19859-90-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-3,5-bis(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-3,5-bis(phenylmethoxy)-(19859-90-6)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-3,5-bis(phenylmethoxy)-(19859-90-6)

Safety Data

• Hazardous Substances Data: 19859-90-6(Hazardous Substances Data)

Upstream product

• 13326-69-7 methyl 3,5-bis(benzyloxy)-4-methoxybenzoate 
• 121-79-9 Propyl gallate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 24093-81-0 methyl 3,5-dihydroxy-4-methoxybenzoate 
• 99-24-1 methyl galloate 
• 180900-28-1 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 19859-89-3 3,5-bis(benzyloxy)-4-methoxybenzoyl chloride 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 180900-30-5 2-(3,5-Bis-benzyloxy-4-methoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 180900-28-1 3-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 180900-32-7 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-dione 
• 180900-48-5 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-4-(3,4,5-trimethoxy-phenyl)-butane-1,4-diol 
• 180900-30-5 2-(3,5-Bis-benzyloxy-4-methoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 
• 1402404-92-5 1,3-bis(benzyloxy)-5-(bromomethyl)-2-methoxybenzene 

Relevant articles and documents

Bioinspired Total Synthesis of Bussealin e

The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent an oxidative phenolic coupling to forge the tetracyclic ring system. The synthesis of the diphenylpropane featured a key sp2-sp3 Hiyama coupling between a vinyldisiloxane and a benzylic bromide.

Total synthesis of (±)-megistophylline I

(±)-Megistophylline I (1), carrying a dienone residue in the acridone framework, was synthesized using the Claisen rearrangement to introduce a prenyl group as a key step.

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.