19860-71-0Relevant articles and documents
New preparation of stereodefined α,α-unsaturated ketones by carbomagnesiation of α-allenyl ketones
Chinkov, Nicka,Morlender-Vais, Natalia,Marek, Ilan
, p. 6009 - 6010 (2002)
The addition of several alkylmagnesium halides to an α-allenyl ketone leads to the corresponding α,β-unsaturated ketones as single geometrical isomers. A π-chelation between the metal and the unsaturation is proposed to explain the steric outcome of this reaction.
Domino gold-catalyzed rearrangement and fluorination of propargyl acetates
De Haro, Teresa,Nevado, Cristina
supporting information; scheme or table, p. 248 - 249 (2011/02/23)
A combination of IPrAuNTf2 as catalyst in the presence of Selectfluor has been successfully used for the high yielding synthesis of α-fluoroenones via 1,3-acyloxy rearrangement of propargyl acetates followed by Csp2-F bond formation,
4,5 Dihydro-(1H)-Pyrazole Derivatives as Cannabinoid CB1 Receptor Modulators
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Page/Page column 12, (2009/01/24)
The invention is directed to 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, to methods for preparing novel intermediates useful for their syntheses, and to methods for preparing compositions. The invention also relates to the uses of compounds and compositions administered to patients to achieve a therapeutic effect in multiple sclerosis, traumatic brain injury, pain including chronic pain, neuropathic pain, acute pain and inflammatory pain, osteoporosis, appetite disorders, epilepsy, Alzheimer's disease, Tourette's syndrome, cerebral ischaemia, emesis, nausea, and gastrointestinal disorders. Compounds of the present disclosure are directed to formula (I): wherein the substituents have the definitions given in the specification.
