19863-70-8Relevant articles and documents
ANTIPARASITIC AGENTS
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Page/Page column 18, (2008/12/08)
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.
cis-Oxypalladation Complexes Derived from (1R,5R)-2(10),3-Pinadiene and Their Utilization in Pd(II)-catalyzed Enantioselective Cyclization of 2-(trans-2-Butenyl)phenols
Hosokawa, Takahiro,Imada, Yasushi,Murahashi, Shun-Ichi
, p. 3282 - 3290 (2007/10/02)
(1R,5R)-2(10),3-Pinadiene, when treated with either Na2PdCl4 in MeOH or Pd(OAc)2 in AcOH and NaCl, gives di-μ-chloro-bis (4a) or (4b), respectively.These complexes represent the firstly isolated cis-oxypalladation adduct.The ligand exchange of 4b with AgOAc affords di-μ-acetato-bis (5b) which serves as the catalyst for the asymmetric cyclization of 2-(trans-2-butenyl)phenols leading to 2-vinyl-2,3-dihydrobenzofurans (13).Although the enantioselectivities induced in this asymmetric cyclization are not high (1-29percent ee), noteworthy is that the cis-complex 5b affords (R)-(-)-enantiomer of 13 while the parent di-μ-acetato-bis give the (S)-isomer.As an application of the present asymmetric cyclization, attempts to synthesize (S)-(+)-tremetone have been made.