198835-06-2

Basic information

• Product Name: TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE
• Synonyms: TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE;5-Oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester;tert-butyl 5-o×o-2-aza-bicyclo[2.2.1]heptane-2-carbo×ylate;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-oxo-, 1,1-diMethylethyl ester;2-Boc-5-oxo-2-aza-bicyclo[2.2.1]heptane
• CAS NO: 198835-06-2
• Molecular Formula: C11H17NO3
• Molecular Weight: 211
• Mol File: 198835-06-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 96 °C
• Boiling Point: 308℃
• Flash Point: 140℃
• Appearance: /
• Density: 1.173
• Storage Temp.: 2-8°C
• PKA: -1.02±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE(198835-06-2)
• EPA Substance Registry System: TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE(198835-06-2)

Safety Data

• Hazardous Substances Data: 198835-06-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate is a chemical compound with the molecular formula C13H21NO3. It is a member of the azabicyclic compound family and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its unique bicyclic structure, which provides it with interesting properties and potential applications in drug design and development. Tert-butyl 5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate has been studied for its potential pharmacological activities and is of interest to the scientific community for further research and exploration.

InChI:InChI=1S/C11H17NO3/c1-11(2,3)15-10(14)12-6-7-4-8(12)5-9(7)13/h7-8H,4-6H2,1-3H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 207405-60-5 (1R,4R)-1,1-Dimethylethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 188345-71-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 1932042-59-5 C₁₁H₁₉NO₃ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 542-92-7 cyclopenta-1,3-diene 
• 198835-03-9 rac-tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 207405-69-4 (1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate 
• 702666-73-7 tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 

Downstream Products

• 1290539-90-0 5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 207405-61-6 5-oximino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1290539-90-0 endo-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1290539-90-0 exo-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 198835-03-9 tert-butyl (1RS,4RS,5RS)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 1290539-90-0 tert-butyl (1R,4R,5R)-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 207405-64-9 tert-butyl (1R,4R)-5-(benzylamino)-2-azabicyclo[2.2.1]heptane-2-carboxylate 
• 198835-03-9 (1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist

A class of novel pyrimidine derivatives bearing diverse conformationally restricted azabicyclic ether/amine were designed, synthesized and evaluated for their GPR119 agonist activities against type 2 diabetes. Most compounds exhibited superior hEC50

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Improved synthesis of monoprotected 5- and 6-amino-2-azanorbornanes

(Chemical Equation Presented) An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments. Copyright Taylor & Francis Group, LLC.