199-54-2 Usage
Description
Benz(e)aceanthrylene, also known as benz[j]aceanthrylene (B[j]A), is a polycyclic aromatic hydrocarbon (PAH) characterized by its complex ring structure. It is a naturally occurring compound that can be found in various environmental sources, such as coal tar and petroleum. Benz(e)aceanthrylene has been identified for its potential role in inducing mutations and its presence in PAH-DNA adducts in lung tissues.
Uses
Used in Environmental and Toxicological Studies:
Benz(e)aceanthrylene is used as a subject of study in environmental and toxicological research for understanding its role in the formation of PAH-DNA adducts in lung tissues. This helps in assessing the potential mutagenic and carcinogenic effects of PAHs, including benz(e)aceanthrylene, on human health.
Used in Cancer Research:
In cancer research, benz(e)aceanthrylene is used as a model compound to investigate its ability to mutate the Ki-ras oncogene in PAH-induced tumors. This application aids in understanding the molecular mechanisms underlying PAH-induced carcinogenesis and the development of lung cancer.
Used in Analytical Chemistry:
Benz(e)aceanthrylene is utilized as a reference compound in analytical chemistry for the identification and quantification of PAHs in various samples, such as air, water, and soil. This application is crucial for monitoring environmental pollution and assessing the potential health risks associated with PAH exposure.
Used in Pharmaceutical Research:
Although not explicitly mentioned in the provided materials, benz(e)aceanthrylene could potentially be used in the pharmaceutical industry as a starting material or intermediate for the synthesis of various drugs or drug candidates. Its complex structure and chemical properties make it a valuable compound for exploring novel therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 199-54-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,9 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 199-54:
(5*1)+(4*9)+(3*9)+(2*5)+(1*4)=82
82 % 10 = 2
So 199-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H12/c1-4-8-17-13(5-1)11-15-9-10-18-16-7-3-2-6-14(16)12-19(17)20(15)18/h1-12H
199-54-2Relevant articles and documents
Synthesis of Cyclopentanobenzanthracene Compounds Related to Carcinogenic Benzanthracene and Cholanthrene Hydrocarbons
Lee, Hongmee,Harvey, Ronald G.
, p. 3787 - 3791 (2007/10/02)
Syntheses of benzaceanthrylene (4a), 8-methylbenzaceanthrylene (4b), and their 1,2-dihydro derivatives (3a,b), as well as 6-methylbenzaceanthrylene (5a) and its 1,2-dihydro derivative (2b) from benzanthracene-7,12-dione are described.Compounds 2b, 3b, 4b, and 5b, all of which contain a methyl group in nonbenzo bay region position, are predicted to be relatively potent carcinogens.
Synthesis of a Series of Novel Polycyclic Aromatic Systems: Isomers of Benzanthracene Containing a Cyclopenta-Fused Ring
Sangaiah, R.,Gold, A.,Toney, G. E.
, p. 1632 - 1638 (2007/10/02)
The four possible isomers of benzanthracene containing a cyclopenta-fused ring have been synthesized and characterized.These systems are of interest for structure-activity studies in bioactivation because of their predicted high level of activity.Formation of fused five-membered rings by intramolecular cyclodehydration, often difficult to accomplish, was found to be smoothly effected in anhydrous HF, provided the reactivity index (Nt) for the appropriate electrophilic addition was favorable.The dihydro polycyclic aromatic alcohols obtained from reduction of the c orresponding keto cyclodehydration products were best dehydrated to the desired PAH by activity grade I neutral alumina in refluxing benzene.This dehydration proceeds in high yield without the formation of isomeric or polymeric side products that occurred even under such mild acid catalysis as p-toluenesulfonic acid.
