199188-97-1

Basic information

• Product Name: (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)
• Synonyms: Fluoxetine IMpurity;N-Methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]formamide;Fluoxetine Hydrochloride Imp. (EP);(3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride);N-ForMylfluoxetine
• CAS NO: 199188-97-1
• Molecular Formula: C18H18F3NO2
• Molecular Weight: 337.3362296
• Mol File: 199188-97-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)(CAS DataBase Reference)
• NIST Chemistry Reference: (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)(199188-97-1)
• EPA Substance Registry System: (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride)(199188-97-1)

Safety Data

• Hazardous Substances Data: 199188-97-1(Hazardous Substances Data)

Usage

Description

(3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride (2-TrifluoroMethylIsomer of Fluoxetine Hydro-chloride) is a chemical compound with potential pharmacological activities. It is a derivative of the antidepressant drug fluoxetine and is proposed to have similar effects in the treatment of mood disorders and anxiety. As a selective serotonin reuptake inhibitor (SSRI), it works by increasing the levels of serotonin in the brain, which can help regulate mood and reduce symptoms of depression. Additionally, as a trifluoromethyl derivative, it may have enhanced potency and improved pharmacokinetic properties compared to the original compound.

Uses

Used in Pharmaceutical Industry:
(3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride (2-TrifluoroMethylIsomer of Fluoxetine Hydro-chloride) is used as a potential antidepressant or anxiolytic medication for the treatment of mood disorders and anxiety. Its mechanism of action involves increasing serotonin levels in the brain, which can help regulate mood and reduce depressive symptoms. The trifluoromethyl derivative may also offer enhanced potency and improved pharmacokinetic properties, making it a promising candidate for further research and development in the pharmaceutical industry.

Upstream product

• 54910-89-3 FLUOXETINE 
• 2258-42-6 formyl acetic anhydride 
• 68-12-2 N,N-dimethyl-formamide 
• 56296-78-7 Adofen 

Relevant articles and documents

Copper catalyzed: N-formylation of α-silyl-substituted tertiary N-alkylamines by air

A site-selective method to prepare N-formyl amines efficiently that relies on the copper(i)-catalyzed oxidation of α-silyl-substituted tertiary N-alkylamines by air at room temperature is described. The oxidative protocol was shown to exhibit excellent functional group tolerance as it was applicable to a wide variety of amine substrates and a number of bioactive molecules and natural products. Moreover, it delinates a ligand-and additive-free amine oxidation process mediated by a low-cost metal salt with oxygen from air taking on the role of both the terminal oxidant and as part of the formylation reagent, which is unprecedented in copper catalysis. It also offers the first synthetic method that can selectively generate α-amino radical species as reactive intermediates from α-silylamines under non-photochemical reaction conditions.

Method for preparing formamide derivative by using catalyst-free transamination reaction

The invention discloses a method for synthesizing a formamide derivative by using a low-reactive catalyst-free and solvent-free tertiary amide and aliphatic amine transamination reaction, wherein thehigh-yield formamide derivative is obtained by directly using N,N-dimethylformamide (DMF) as a formyl source. According to the present invention, the method has advantages of inexpensive and easily available raw materials, inexpensive and easily available acylating reagent, high reaction yield, one-step reaction, low cost, high reaction selectivity, simple operation and the like, and can overcomethe defects of high toxicity of the reaction reagent, requirement of different types of catalysts, high cost, more reaction steps, more by-products and the like in the prior art.

Cobalt(II)-Catalyzed N-Acylation of Amines through a Transamidation Reaction

A practical protocol has been developed for a Co(OAc)2·4H2O-catalyzed transamidation reaction. The reaction gives high yields and uses N,N-dimethylformamide and other amides as carbonyl sources. The protocol is rapid and simple, and it does not require any acids, bases, ligands, or other additives. It works well for a wide range of primary, secondary, and heterocyclic amines.