199383-77-2

Basic information

• Product Name: (S)-4-Cyano-4-phenylcyclohex-1-enyl acetate
• Synonyms: (S)-4-Cyano-4-phenylcyclohex-1-enyl acetate
• CAS NO: 199383-77-2
• Molecular Weight: 241.29
• Mol File: 199383-77-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-4-Cyano-4-phenylcyclohex-1-enyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Cyano-4-phenylcyclohex-1-enyl acetate(199383-77-2)
• EPA Substance Registry System: (S)-4-Cyano-4-phenylcyclohex-1-enyl acetate(199383-77-2)

Safety Data

• Hazardous Substances Data: 199383-77-2(Hazardous Substances Data)

Upstream product

• 25115-74-6 4-cyano-4-phenylcyclohexanone 
• 303728-44-1 4-Cyano-4-phenylcyclohex-1-enyl acetate 
• 108-24-7 acetic anhydride 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 199383-85-2 (S)-4-Oxo-1-phenyl-cyclohex-2-enecarbonitrile 

Relevant articles and documents

Chemoenzymatic synthesis of a non-peptide tachykinin NK-2 antagonist

The synthesis of a tachykinin NK-2 antagonist (S)-11 has been carried out in four steps starting from the the (S)-(+)-enol acetate 3, which was obtained in 100% e.e. by resolution of the racemic ester with Pseudomonas fluorescens lipase. The absolute configuration of the enol acetate (+)-3 was confirmed by X-ray analysis of the camphanyl derivative 13. (C) 2000 Elsevier Science Ltd.

Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes

Desymmetrisation of 4-cyano-4-phenylcyclohexanone 1 has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived racemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol aceate (-)-(S)-2 (100% e.e.) obtained was determined by X-ray analysis of the camphanyl derivative 7.