199442-68-7

Basic information

• Product Name: N-(2-Amino-pyridin-3-yl)-4-methyl-benzenesulfonamide
• Synonyms: N-(2-Amino-pyridin-3-yl)-4-methyl-benzenesulfonamide
• CAS NO: 199442-68-7
• Molecular Weight: 263.32
• Mol File: 199442-68-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-Amino-pyridin-3-yl)-4-methyl-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Amino-pyridin-3-yl)-4-methyl-benzenesulfonamide(199442-68-7)
• EPA Substance Registry System: N-(2-Amino-pyridin-3-yl)-4-methyl-benzenesulfonamide(199442-68-7)

Safety Data

• Hazardous Substances Data: 199442-68-7(Hazardous Substances Data)

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 199442-69-8 N-(2-Amino-pyridin-3-yl)-4,N-dimethyl-benzenesulfonamide 
• 105650-23-5 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine 
• 107351-81-5 2-amino-3-methylamino-5-phenylpyridine 
• 125572-33-0 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine 
• 199442-70-1 N-(2-Amino-5-iodo-pyridin-3-yl)-4,N-dimethyl-benzenesulfonamide 

Relevant articles and documents

An easy photochemical approach to the synthesis of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Mutations induced by substances formed during food cooking are a field of growing interest; for a better comprehension of the mechanism of action of these carcinogens, simple routes to their synthesis are needed. In this letter we describe an easy method for 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) synthesis, starling from the commercially available 2,3- diaminopyridine 1 via the 2-amino-3-methylamino-5-phenylpyridine 5 formation. The key step of this approach is the one pot synthesis of 5 performed by photolysis of 2-amino-5-iodo-3-(N-methyl-N-tosylamino)pyridine 4 to obtain simultaneous phenylation and tosyl group removal. Compound 5 was then used as an intermediate to obtain the 1-methyl 6-phenylimidazo[4,5-b]pylidine 6 which was aminated to afford PhIP in good overall yields.