199445-88-0Relevant articles and documents
An efficient method for the transformation of naturally occurring monoterpenes into amines through rhodium-catalyzed hydroaminomethylation
Melo, Daniela S.,Pereira-Júnior, Schubert S.,Dos Santos, Eduardo N.
, p. 70 - 76 (2012)
The hydroaminomethylation (hydroformylation/reductive amination) of the naturally occurring monoterpenes, i.e., limonene, camphene, and β-pinene, was studied having as condensation counterparts the amines di-n-butylamine, morpholine or n-butylamine. Moderate to good yields (75-94%) were obtained employing [Rh(cod)(μ-OMe)]2 as pre-catalyst in the presence or not of triphenylphosphine or tribenzylphosphine as ancillaries in toluene, at 100 °C and 60 bar of an equimolar mixture of carbon monoxide and hydrogen. Some of the hydroaminomethylation products derived from limonene have biological activity and the products derived from camphene and β-pinene are new.
