199456-58-1

Basic information

• Product Name: Benzoic acid, 4-[2-(dimethylhydrazono)ethyl]-, methyl ester
• CAS NO: 199456-58-1
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Mol File: 199456-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[2-(dimethylhydrazono)ethyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-(dimethylhydrazono)ethyl]-, methyl ester(199456-58-1)
• EPA Substance Registry System: Benzoic acid, 4-[2-(dimethylhydrazono)ethyl]-, methyl ester(199456-58-1)

Safety Data

• Hazardous Substances Data: 199456-58-1(Hazardous Substances Data)

Upstream product

• 57-14-7 N,N-Dimethylhydrazine 
• 106918-32-5 4-carbomethoxyphenylacetaldehyde 

Downstream Products

• 199456-61-6 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 199456-70-7 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-acetyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 199456-62-7 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 145298-15-3 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-formyl-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 199456-63-8 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-formyl-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 182217-62-5 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-pivaloylamino-4(3H)-oxo-quinazoline 
• 199456-65-0 4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoic acid methyl ester 
• 199456-60-5 4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoic acid 
• 182217-65-8 6-[2'-Formyl-2'-(4-carbomethoxy phenyl)-ethyl]-2-amino-4(3H)-oxoquinazoline 
• 199456-59-2 4-{1-(Dimethyl-hydrazonomethyl)-2-[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-quinazolin-6-yl]-ethyl}-benzoic acid methyl ester 

Relevant articles and documents

10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase

The synthesis of 10-formyl-5,8,10-trideazafolic acid (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) is reported. The target compound was prepared by a convergent synthesis utilizing the alkylation of hydrazone 5 with benzylic bromide 6 to construct the core heterocycle 7. The aldehyde 3 and related agents were evaluated as inhibitors of purN GAR Tfase and avian AICAR Tfase. Compound 3 exhibited potent inhibition of GAR Tfase with a K(i) of 0.26 ± 0.05 μM. In contrast, 3 exhibited more moderate inhibition of aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), with K(i) of 7.6 ± 1.5 μM.