199464-34-1

Basic information

• Product Name: C₂₂H₂₀O₇
• Synonyms: C₂₂H₂₀O₇
• CAS NO: 199464-34-1
• Molecular Weight: 396.397
• Mol File: 199464-34-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₀O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₀O₇(199464-34-1)
• EPA Substance Registry System: C₂₂H₂₀O₇(199464-34-1)

Safety Data

• Hazardous Substances Data: 199464-34-1(Hazardous Substances Data)

Upstream product

• 106636-74-2 4-bromo-4-deoxypodophyllotoxin 

Downstream Products

• 1014671-34-1 (-)-podophyllotoxin 
• 3590-93-0 4'-demethyl-4-deoxypodophyllotoxin 

Relevant articles and documents

Design, synthesis and biological evaluation of 4′-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors

A new class of 4′-demethyl-4-deoxypodophyllotoxin derivatives has been designed and synthesized as tubulin-HDAC dual inhibitors. Biological evaluation of these hybrids included the inhibitory activity of HDAC, in vitro cell cycle analysis in HCT-116 cells as well as cytotoxicity against two cancer cell lines (A549 and HCT116). The distance and angle between the HDAC capping group and the zinc binding group were systematically varied. Compounds 14a and 14c showed most potent dual inhibitory activity and powerful antiproliferative activity on HCT116 and A549 cell lines. This journal is