19950-79-9

Basic information

• Product Name: 4,9-diisobutyryl-coniferol
• Synonyms: 4,9-diisobutyryl-coniferol
• CAS NO: 19950-79-9
• Molecular Weight: 320.386
• Mol File: 19950-79-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,9-diisobutyryl-coniferol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,9-diisobutyryl-coniferol(19950-79-9)
• EPA Substance Registry System: 4,9-diisobutyryl-coniferol(19950-79-9)

Safety Data

• Hazardous Substances Data: 19950-79-9(Hazardous Substances Data)

Upstream product

• 79-30-1 isobutyryl chloride 
• 458-35-5 coniferal alcohol 
• 97-72-3 2-Methylpropionic anhydride 
• 2309-07-1 Methyl ferulate 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 121-33-5 vanillin 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Relevant articles and documents

Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs

A new coniferol derivative, named as tripolinolate A (1), and 11 known compounds (2-12) were isolated from whole plants of Tripolium vulgare Nees. The structure of this new compound was determined as 4-(2S-methylbutyryl)-9-acetyl-coniferol based on its NMR and HRESIMS spectral analyses. A simple and efficient method was designed to prepare tripolinolate A and its 19 analogs including nine new chemical entities for bioactive assay. Tripolinolate A and its analog 4,9-diacetyl-coniferol were found to be the two most active compounds that significantly inhibited the proliferation of different cancer cell lines with IC50 values ranging from 0.36 to 12.9 μM and induced apoptosis in tumor cells. Structure-activity relationship analysis suggested that the molecular size of acyl moieties at C-4 and C-9 position might have an effect on the activity of this type of coniferol derivatives.