199597-32-5

Basic information

• Product Name: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-pyridin-2-ylmethyl) ester O'-(2-cyano-ethyl) ester
• CAS NO: 199597-32-5
• Molecular Weight: 835.338
• Mol File: 199597-32-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-pyridin-2-ylmethyl) ester O'-(2-cyano-ethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-pyridin-2-ylmethyl) ester O'-(2-cyano-ethyl) ester(199597-32-5)
• EPA Substance Registry System: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-pyridin-2-ylmethyl) ester O'-(2-cyano-ethyl) ester(199597-32-5)

Safety Data

• Hazardous Substances Data: 199597-32-5(Hazardous Substances Data)

Upstream product

• 199597-29-0 C₃₄H₃₆N₃O₈PS 
• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 10177-21-6 4-chloro-2-chloromethyl pyridine 

Relevant articles and documents

Synthesis of oligodeoxynucleoside phosphoromonothioates and phosphorodithioates by a phosphotriester method

A phosphotriester method for the synthesis of dithymidine phosphoromonothioates and phosphorodithioates with new S-protecting groups has been investigated. Four of the S-protecting groups possesed catalytic activity, however side reactions occurred during deprotection. The best S- protecting group was 4-chloro-2-nitrobenzyl which could be removed with a minimum of side reactions (0.3 %). The coupling reagent PyFNOP (14) gave protected dithymidine phosphoromonothioate in 96 % yield after 15 rain coupling. Furthermore PyFNOP chemoselectively activates oxygen in nucleoside phosphorodithioate monomers 9 and can be used for the synthesis of oligodeoxynucleoside phosphorodithioates with mixed base sequences.