1996-30-1

Basic information

• Product Name: 2-Bromo-4-chloro-1-fluorobenzene
• Synonyms: 1-BROMO-5-CHLORO-2-FLUOROBENZENE;1-BROMO-3-CHLORO-6-FLUOROBENZENE;2-BROMO-4-CHLORO-1-FLUOROBENZENE;2-FLUORO-5-CHLOROBROMOBENZENE;3-BROMO-1-CHLORO-4-FLUOROBENZENE;3-BROMO-4-FLUOROCHLOROBENZENE;1-BROMO-2-FLUORO-5-CHLOROBENZENE;2-Bromo-4-chloro-1-fluorobenzene97%
• CAS NO: 1996-30-1
• Molecular Formula: C₆H₃BrClF
• Molecular Weight: 209.44
• Product Categories: Aromatic Halides (substituted);Bromine Compounds;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorinated benzene series;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 1996-30-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 180 °C
• Flash Point: 180°C
• Appearance: /
• Density: 1.719
• Vapor Pressure: 0.622mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-4-chloro-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-chloro-1-fluorobenzene(1996-30-1)
• EPA Substance Registry System: 2-Bromo-4-chloro-1-fluorobenzene(1996-30-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 1996-30-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C6H3BrClF/c7-5-3-4(8)1-2-6(5)9/h1-3H

Upstream product

• 873-38-1 4-chloro-2-bromoaniline 
• 1000572-73-5 1-bromo-5-chloro-2-fluoro-4-iodo-benzene 

Downstream Products

• 657425-05-3 ((2-fluoro-5-chlorophenyl)ethynyl)trimethylsilane 
• 1225276-81-2 C₁₉H₂₅ClFNO₃ 
• 1242156-97-3 2-bromo-6-chloro-3-fluorobenzaldehyde 
• 882689-76-1 [(2-bromo-4-chlorophenyl)thio]acetic acid 
• 1269440-82-5 3-bromo-5-chloro-2-fluorobenzaldehyde 
• 1269232-93-0 3-bromo-5-chloro-2-fluorobenzoic acid 
• 1269232-94-1 tert-butyl 3-bromo-5-chloro-2-fluorophenyl-carbamate 
• 1269232-95-2 3-bromo-5-chloro-2-fluoroaniline 
• 1269440-69-8 tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate: 
• 1269440-09-6 methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate 
• 1269440-77-8 (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(tert-butoxycarbonylamino)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate 
• 1269440-78-9 (S)-methyl 1-(4-(3-(3-amino-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate 
• 1269440-17-6 methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate 
• 1269440-99-4 (S)-methyl 1-(4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate 

Relevant articles and documents

Chemoselective Radical Dehalogenation and C-C Bond Formation on Aryl Halide Substrates Using Organic Photoredox Catalysts

Despite the number of methods available for dehalogenation and carbon-carbon bond formation using aryl halides, strategies that provide chemoselectivity for systems bearing multiple carbon-halogen bonds are still needed. Herein, we report the ability to tune the reduction potential of metal-free phenothiazine-based photoredox catalysts and demonstrate the application of these catalysts for chemoselective carbon-halogen bond activation to achieve C-C cross-coupling reactions as well as reductive dehalogenations. This procedure works both for conjugated polyhalides as well as unconjugated substrates. We further illustrate the usefulness of this protocol by intramolecular cyclization of a pyrrole substrate, an advanced building block for a family of natural products known to exhibit biological activity.