1996-66-3

Basic information

• Product Name: Benzenemethanol, 4-chloro-a-phenyl-a-(trifluoromethyl)-
• CAS NO: 1996-66-3
• Molecular Formula: C14H10ClF3O
• Molecular Weight: 286.681
• Mol File: 1996-66-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-chloro-a-phenyl-a-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-chloro-a-phenyl-a-(trifluoromethyl)-(1996-66-3)
• EPA Substance Registry System: Benzenemethanol, 4-chloro-a-phenyl-a-(trifluoromethyl)-(1996-66-3)

Safety Data

• Hazardous Substances Data: 1996-66-3(Hazardous Substances Data)

Usage

Chemical Class

Benzyl alcohols

Physical Appearance

White to off-white solid

Solubility

Insoluble in water, soluble in organic solvents

Primary Use

Key intermediate for synthesis of other organic compounds

Applications

Pharmaceuticals
Agrochemicals
Academic research chemicals

Potential

Building block for new materials and substances

Value

Widely used in organic chemistry

Upstream product

• 75-46-7 trifluoromethan 
• 134-85-0 4-chlorobenzophenone 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS

PROBLEM TO BE SOLVED: To provide a method for producing CF3 group-containing alcohols useful as production intermediates for medicines and agrochemicals. SOLUTION: The method for producing CF3 group-containing alcohols represented by formula (2) comprises

The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones.